THE SCIENCE

Ingredients

  1. A prospective, randomised double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of Ashwagandha root in reducing stress and anxiety in adults. Chandrasekhar, K., Kapoor, J., & Anishetty, S. (2012). Indian journal of psychological medicine, 34(3), 255.
  2. Trial Choudhary, D., Bhattacharyya, S., & Joshi, K. (2017). Journal of evidence-based complementary & alternative medicine, 22(1), 96-106.
  3. Efficacy and Safety of Ashwagandha (Withania somnifera (L.) Dunal) Root Extract in Improving Memory and Cognitive Functions Choudhary, D., Bhattacharyya, S., & Bose, S. (2017). Journal of Dietary Supplements, 1-14. Chicago
  4. Cognizin® Citicoline Increases Motor Speed and Attention in Healthy Adolescent Males Daily Cognizin® citicoline supplementation also improved motor speed and decreased impulsivity in study participants.
  5. Cognizin® Citicoline Improves Attentional Performance in Healthy Adult Women Citicoline showed significantly better ability to produce correct responses on the CPT- II, likely due to improved cognitive inhibition. Our findings suggest that citicoline may improve attentional performance in middle- aged women and may ameliorate attentional deficits associated with central nervous system disorders.
  6. Cognizin® Citicoline Increases Brain Energy (ATP) by 14% and Speeds up Formation of Brain Membranes by 26% in Healthy Adults These data demonstrate that Citicoline- related alterations in brain neurochemistry are regionally specific and suggest that oral Citicoline administration improves cellular bioenergetics of the anterior cingulate cortex. These findings have important implications, given that maintenance of PCr and beta NTP levels have been shown to be neuroprotective.
  7. Citicoline Improves Memory Performance in Elderly Subjects This study, carried out by the EuroEspes Biomedical Research Center in Spain, concludes that the citicoline molecule is suitable for the treatment of memory deficits in old people.
  8. Kell G, et al. affron® a novel saffron extract (Crocus sativus L.) improves mood in healthy adults over 4 weeks in a double-blind, parallel, randomised, placebo-controlled clinical trial. Complement Ther Med. 2017 Aug;33:58-64
  9. Lopresti AL, et al. Efficacy of curcumin, and a saffron/curcumin combination for the treatment of major depression: A randomised, double-blind, placebo- controlled study. J Affect Disord. 2017 Jan 1;207:188-196.
  10. Lopresti AL, et al. affron®, a standardised extract from saffron (Crocus sativus L.) for the treatment of youth anxiety and depressive symptoms: A randomised, double-blind, placebo-controlled study. J Affect Disord. 2018 May;232:349-357.
  11. Nishide, A, et al. Sleep enhancement by saffron extract in randomised control trial, Japanese Pharmacology and Therapeutics. Japanese Pharmacology and Therapeutics. 2018 (8); 46:1407-1415.
  12. Lopresti AL, et al. New clinical evidence of affron® efficacy as an adjunct treatment for unremitted depression. J Psychopharmacol. 2019. Nov;33(11):1415-1427.
  13. https://pubmed.ncbi.nlm.nih.gov/32599787/
  14. https://pubmed.ncbi.nlm.nih.gov/27655070/
  15. https://pubmed.ncbi.nlm.nih.gov/28248558/
  16. https://pubmed.ncbi.nlm.nih.gov/33809274/
  17. https://pubmed.ncbi.nlm.nih.gov/29186856/
  18. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5543500/

 

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